Jovaniel Rodríguez Maldonado: nuestros estudiantes en internados de verano 2017

Mi nombre es Jovaniel Rodríguez Maldonado, pertenezco al departamento de química de la Universidad de Puerto Rico, Recinto de Rio Piedras y comienzo mi 4to año este próximo semestre. Como parte del programa IDI-BD2K tuve la oportunidad de participar en el Summer Program in Biostatistics and Computational Biology en el Harvard T.H. Chan School of Public Health.

Durante 6 semanas trabaje junto al Dr. Corwin Zigler y el Dr. Chanmin Kim en trazar y predecir el movimiento de emisiones de sulfato (SO4) a partir del dióxido de azufre (SO2) que emiten las plantas de energía eléctrica en los Estados Unidos. La pregunta principal era saber que personas están respirando los contaminantes emitidos por cada planta. Para esto utilizamos datos que contenían información de todas las plantas ubicadas en los Estados Unidos, incluyendo los niveles de emisiones por día y sus coordenadas. De igual manera utilizamos datos que contenían información sobre detectores de particulado menores de 2.5 micrómetros (PM2.5) en todos los Estados Unidos incluyendo los niveles de particulado por día y sus coordenadas. Con esta información creamos un modelo de regresión lineal que tomaba en cuenta la mayoría de los factores que pueden causar variabilidad en las emisiones para encontrar una asociación entre las emisiones y los detectores. Finalmente creamos una aplicación en shiny utilizando el modelo y los datos espaciales que compara el modelo estadístico que creamos con el modelo HYSPLIT que es utilizado actualmente en este tipo de investigación. Este modelo toma factores como el viento e imágenes satelitales para crear sus predicciones mientras que el nuestro es estrictamente matemático. En adición a la investigación tuve la oportunidad de tomar clases de bioestadísticas y epidemiología a nivel graduado. Tuve la oportunidad de conocer a la facultad de la universidad y a muchísimas personas en áreas tanto académicas como en la industria. Una de las experiencias más emocionantes fue visitar el Broad Institute, que es un centro de investigación genómica aplicado a las ciencias biomédicas creado en conjunto entre MIT y Harvard.

Al final del internado tuvimos la oportunidad de presentar nuestros resultados en The Dana Farber Cancer Institute como parte del Pipelines into Biostatistics Symposium y discutirlos con personas expertas en el área. Estoy sumamente agradecido con el programa BD2K y con Harvard por darme esta oportunidad. Es una experiencia inolvidable, llena de retos y de crecimiento tanto personal como estudiantil y profesional. Se lo recomiendo a todo el que esté interesado, lo único que se necesita es ganas de aprender y estar abierto a nuevas áreas de estudio.

Jovaniel Rodríguez Maldonado, IDI-BD2K student at Harvard for a summer internship.

Alexandra Carruthers Ferrero: Nuestros estudiantes en internados de verano 2017

Hi! I am Alexandra Carruthers Ferrero. I am currently an undergraduate physics major at the University of Puerto Rico, Río Piedras Campus. This summer, I participated in Harvard T.H. Chan School of Public Health‘s Summer Program in Biostatistics and Computational Biology through IDI-BD2K (Increasing Diversity in Interdisciplinary Big Data to Knowledge). Thanks to this incredible opportunity, I was able to work on a public health research project under the mentorship of Dr. Cory Zigler and Dr. Chanmin Kim. The project focused on tracking air pollution from coal power plants throughout the United States. We worked with time-varying data to construct linear regression models and learn how the emissions of certain power plants spread and impact populations throughout the country. Traditionally, chemical and physical models are used to study the spread of air pollution. Therefore, another key point of our project was to compare the results of a purely data based statistical model with those of chemical and physical models. In addition to working on a research project, the program provided us with professional workshops and courses in biostatistics and epidemiology.

I cannot say enough how grateful I am to have had the opportunity to take classes and research in the school of public health this past summer. It provided an environment for not only professional but also personal growth. I wholeheartedly recommend others to participate!

Jovaniel, Alexandra, David and Dr. Chanmin Kim show us the Zigler Lab

Stephanie Colón Marrero: Nuestros estudiantes en internados de verano 2017

My name is Stephanie Colón Marrero and I am a Biology undergraduate student at University of Puerto Rico, Rio Piedras Campus (UPR-RP). This past summer I participated in the Internship in Biomedical Research, Informatics, and Computer Science (iBRIC) from the Department of Biomedical Informatics at the University of Pittsburgh. I had the opportunity to work alongside Dr. Qiming Jane Wang and Dr.
Sahdeo Prasad, from the Department of Pharmacology and Chemical Biology at the University of Pittsburgh School of Medicine, on a research project that aimed to exploit the therapeutic potential of combining protein kinase D inhibitors with chemotherapeutic agents for prostate cancer treatment. We first studied the potential of these drugs to inhibit cell proliferation and cell migration, fundamental biological processes implicated in cancer development and progression, by performing cell viability and wound-healing assays, respectively. Our findings contribute to a mouse prostate cancer metastasis model currently being developed in the Wang laboratory.

At the end of the program, I participated in the Summer Research Symposium at Duquesne University. I encourage every student interested in bioinformatics and biomedical research to take part in the research opportunity offered by the Increasing Diversity in Interdisciplinary Big Data to Knowledge (IDI-BD2K) program. Participating in research programs, like iBRIC, provides valuable tools that could improve significantly your personal and professional growth.

Stephanie Colon presenting at the Summer Research Symposium at
Duquesne University.

Israel O. Dilán-Pantojas: Nuestros estudiantes en internados de verano 2017

Hola soy Israel O. Dilán-Pantojas, estudiante del programa de bachillerato de estudios generales, tengo la meta de completar una segunda concentración en Ciencias de Cómputos. Este próximo año sería mi 7mo año de estudio en la Universidad de Puerto Rico, y actualmente participo activamente en grupos de investigación de Biomedicina y Bioinformática.

Este verano he estado trabajando, con investigación en el campo de Descubrimiento Causal con modelos gráficos, en el Centro para el Descubrimiento Causal bajo la tutela del Dr. Greg Cooper y la mentoria del estudiante graduado Bryan Andrews. Este campo busca identificar correctamente la orientación de de relaciones de causalidad, es decir si un agente o causa A controla el resultado de una variable dependiente o efecto B. Ósea, A y B no están casualmente relacionado (A    B),  A causa B (A -> B), B causa A (A <- B) o ambos A y B están mediados por otro agente que los causa a ambos (A<->B). Actualmente los algoritmos que hacen este trabajo están limitados identificando ciertas orientaciones causales como A — B — C, ya que la misma es equivalente en los siguientes tres casos A –> B –> C, A <– B –> C, A <– B <– C. Nuestro trabajo busca poder distinguir entre estos tres casos utilizando información de intervenciones llevadas a cabo por los investigadores y representadas como variables diferentes en los modelos, lo que nos permitirán orientar con certeza este tipo de relaciones causales.

Israel Dilán at Pittsburgh.

Andres Lopez Rivas: Nuestros estudiantes en internados de verano 2017

Hi! I am Andres Lopez Rivas, a Biology undergraduate student at the University of Puerto Rico, Río Piedras campus. Thanks to the IDI-BD2K program, I am currently on an Internship in Biomedical Research, Informatics and Computer Science (iBRIC) at the University of Pittsburgh. Working with professor Takis Benos, I collaborated with graduate students on a groundbreaking research, examining gene expression and pathway analysis involved in resistance to PD-1/PD-L1 immunotherapy on melanoma patients. We are trying to identify biomarkers that can predict the outcome of the patient’s cancer when the immunotherapy is delivered. Understanding the mechanism involved in this immunotherapy is not only important in melanoma patients but also in numerous cancer types like kidney, bladder, non-small cell lung and others since the pathway that this therapy triggers governs in a multitude of cancer types. Nowadays the researchers of medicine, as well as researchers in other branches of investigation, must assume a more interdisciplinary role to encompass the challenges and find a solution. This program not only deepened my knowledge in biology, mathematics and computer science but also gave me the tools to apply it to problems that every researcher in my field faces. At the end of the week all of the interns will be presenting a poster at Duquesne University along with other interns from different programs. Although it has been a challenging 10 week internship, my colleagues and I have been enjoying every minute of it by going to baseball games, festivals, museums, theaters, concerts and many other things the city of Pittsburgh has to offer.

Andres Lopez presenting his poster.

Louis Gil: Nuestros estudiantes en internados de verano 2017

Hi, my name is Louis Gil. I’m a senior from the University of Puerto Rico Rio Piedras Campus, Department of Computer Science. This summer thanks to the IBD2k program, I worked in a computational genomics
research project in UPMC Shadyside Hospital as part of the University of Pittsburgh and DBMI program iBRIC with my mentor William LaFramboise. Here I worked in my first sequencing lab, having the first-hand experience of having your data created right next to you is an amazing feeling, it’s like getting bread right out the oven.

I’m working with papillary renal cell carcinomas which are rare form of kidney cancer that have been sub-classified into type 1 (PP1) and Type 2 (PP2) based on phenotypic differences. Here we were tasked to find molecular difference between these two classes. By then comparing these data sets we could later infer a pathway for each type, such that we can then distinguish main drivers and differences of both subclasses. We worked with expression data, CNV’s, SNP’s and indels, and used tools that were all new to me such as Galaxy (VarScan), Nexus, NIH David, Genome Oncology Browser and IPA (Ingenuity). This hands-on approach to all these tools was a great experience and facing hurdles along the way just motivates you to keep going and not make mistakes.

Pittsburgh is a great city filled with amazing and lovely people and every corner seemed to be an adventure. I also attended many conferences and talks where I learned of new technologies like Tetrad, learned about graduate school and how to improve my skills in presenting and overall skills associated to my field. I made great friends and contacts that will help me in the future to become a better person and professional.

Louis Gil in his work area at UPMC Shadyside Hospital.

Jaziel Torres: Nuestros estudiantes en internados de verano 2017

Soy Jaziel Torres, estudiante subgraduado del Departamento de Matemáticas (UPR-RP), y este próximo semestre comenzaré mi tercer año. Gracias al programa IDI-BD2K me encuentro participando del programa iBRIC (Internship in Biomedical Research, Informatics, and Computer Science) en la Universidad de Pittsburgh. Estoy trabajando con el Dr. Panos K. Chrysanthis y el estudiante graduado Xiaoyu Ge, del departamento de Ciencias de Cómputos de la Universidad de Pittsburgh, en una plataforma experimental que le recomienda al usuario, basado en su localización y sus preferencias, un conjunto de lugares o establecimientos diversos y relevantes para el usuario, los cuales puede visitar. Específicamente mi investigación se enfoca en desarrollar un algoritmo que recomiende una ruta que se pueda completar en menos de una cantidad determinada de tiempo, pasando por una cantidad determinada de lugares o establecimientos y que esa ruta maximice la relevancia de los lugares o establecimientos a visitar, y manteniendo la diversidad de la ruta, tal que dos establecimientos del mismo tipo no sean visitados consecutivamente.
Palabras claves de mi investigación: Informática urbana (Urban Informatics), Problema de satisfacción de condiciones (Constraint Satisfaction Problem), Sistemas de recomendación (Recommender Systems)

Student Publication

Ivan Jimenez-Ruiz, IDI-BD2k student, went to our partner institution, the Center for Causal Discovery in Pittsburgh last summer for an internship.

This summer he will present work done at his Summer 2016 internship at the Practice & Experience in Advanced Research Computing Conference Series (PEARC’17) conference July 9-13, 2017 in New Orleans, Louisiana, USA.

After that, he will be starting PhD studies in North Carolina. We wish you the best Ivan!

  1. I. Jimenez-Ruiz, R. Gonzalez-Mendez, A. Ropelewski. 2017. In Proceedings of ACM PEARC conference, New Orleans, USA, July 2017 (PEARC’17), 4 pages. http://dx.doi.org/10.1145/3093338.3093372

Local copy:

ILJR_PEARC_Final_Draft

¡Nuestros estudiantes en internados de verano 2016!

Hi! My name is Iván Jiménez and I am a senior Computer Science undergrad at the University of Puerto Rico, Rio Piedras Campus (UPRRP). Through the UPRRP’s Increasing Diversity in Interdisciplinary Big Data to Knowledge (IDI-BD2K) program, I was able to participate in the Internship in Biomedical Research, Informatics and Computer Science (iBRIC) during this summer. I worked with Alexander Ropelewski at the Pittsburgh Supercomputing Center (PSC) in Pittsburgh, Pennsylvania. We worked in collaboration with the Department of Biomedical Informatics (DBMI) of the University of Pittsburgh on our project titled “Optimizing High Performance Big Data Cancer Workflows”. The project consisted of running cancer workflows on different file systems of PSC’s new supercomputer: Bridges. We optimized these workflows in terms of execution timings and memory usage and then produced recommendations for future use of programs on each file system.

I also had the chance to develop a project poster and present it at the annual Duquesne Summer Undergraduate Research Symposium at Duquesne University. Our work has been recently accepted for publishing as a student paper for the Practice and Experience in Advanced Research Computing (PEARC-2017) conference.

Apart from work, one of the best highlights of my summer was touring the PSC, UPitt and Carnegie Mellon campuses and buildings with my fellow interns. The list of awesome activities we did as a group is too long to mention in this summary so I’ll just include the schedule we tried to follow throughout the internship.

Thanks to the IDI-BD2K program, I will never forget fun I had while meeting new people, eating lots of pizza and learning about Bioinformatics and High Performance Computing.